| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50509714 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1839122 (CHEMBL4339337) |
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| IC50 | 961±n/a nM |
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| Citation |  AlFadly, ED; Elzahhar, PA; Tramarin, A; Elkazaz, S; Shaltout, H; Abu-Serie, MM; Janockova, J; Soukup, O; Ghareeb, DA; El-Yazbi, AF; Rafeh, RW; Bakkar, NZ; Kobeissy, F; Iriepa, I; Moraleda, I; Saudi, MNS; Bartolini, M; Belal, ASF Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. Eur J Med Chem167:161-186 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
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| Type: | Enzyme |
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| Mol. Mass.: | 67792.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22303 |
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| Residue: | 614 |
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| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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| BDBM50509714 |
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| n/a |
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| Name | BDBM50509714 |
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| Synonyms: | CHEMBL4459154 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O2S2 |
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| Mol. Mass. | 427.543 |
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| SMILES | NS(=O)(=O)c1ccc(NC(=S)NNc2c3CCCCc3nc3ccccc23)cc1 |
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| Structure | 
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