Reaction Details |
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Target | Melanocortin receptor 4 |
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Ligand | BDBM50017181 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1856756 (CHEMBL4357485) |
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IC50 | 1.3±n/a nM |
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Citation | Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. J Med Chem63:2194-2208 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanocortin receptor 4 |
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Name: | Melanocortin receptor 4 |
Synonyms: | MC4-R | MC4R_MOUSE | Mc4r |
Type: | PROTEIN |
Mol. Mass.: | 36964.43 |
Organism: | Mus musculus |
Description: | ChEMBL_1498850 |
Residue: | 332 |
Sequence: | MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY
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BDBM50017181 |
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n/a |
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Name | BDBM50017181 |
Synonyms: | CHEMBL441738 |
Type | Small organic molecule |
Emp. Form. | C78H111N21O19 |
Mol. Mass. | 1646.8452 |
SMILES | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| |
Structure |
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