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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent serotonin transporter | ||
| Ligand | BDBM50516858 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1867021 (CHEMBL4367996) | ||
| Ki | 240±n/a nM | ||
| Citation |  ?lifirski, G; Król, M; Kleps, J; Podsadni, P; Belka, M; B?czek, T; Siwek, A; Stachowicz, K; Szewczyk, B; Nowak, G; Bojarski, A; Kozio?, AE; Tur?o, J; Herold, F Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT Eur J Med Chem180:383-397 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent serotonin transporter | |||
| Name: | Sodium-dependent serotonin transporter | ||
| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 70168.43 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | P31652 | ||
| Residue: | 630 | ||
| Sequence: |
| ||
| BDBM50516858 | |||
| n/a | |||
| Name | BDBM50516858 | ||
| Synonyms: | CHEMBL4466243 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H37FN4O3 | ||
| Mol. Mass. | 544.6596 | ||
| SMILES | COc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCCC(C2)c2c[nH]c3ccc(F)cc23)c1=O |(34.44,-5.01,;33.1,-5.77,;31.77,-5,;31.78,-3.46,;30.44,-2.68,;29.1,-3.46,;29.1,-4.99,;30.43,-5.76,;30.43,-7.3,;29.1,-8.07,;27.77,-7.29,;26.44,-8.07,;26.44,-9.61,;27.77,-10.37,;29.09,-9.61,;30.41,-10.38,;30.4,-11.92,;31.75,-9.62,;33.08,-10.4,;34.42,-9.63,;35.75,-10.41,;37.09,-9.65,;38.42,-10.43,;39.74,-9.67,;41.07,-10.45,;41.06,-11.99,;39.72,-12.75,;38.4,-11.97,;39.71,-14.29,;38.45,-15.18,;38.91,-16.65,;40.45,-16.66,;41.47,-17.82,;42.97,-17.51,;43.46,-16.05,;44.97,-15.74,;42.44,-14.9,;40.94,-15.21,;31.76,-8.08,;33.1,-7.31,)| | ||
| Structure | 
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