| Reaction Details |
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 | Report a problem with these data |
| Target | Matrilysin |
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| Ligand | BDBM50072578 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_102124 |
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| IC50 | 3.6±n/a nM |
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| Citation |  Sheppard, GS; Florjancic, AS; Giesler, JR; Xu, L; Guo, Y; Davidsen, SK; Marcotte, PA; Elmore, I; Albert, DH; Magoc, TJ; Bouska, JJ; Goodfellow, CL; Morgan, DW; Summers, JB Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors. Bioorg Med Chem Lett8:3251-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrilysin |
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| Name: | Matrilysin |
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| Synonyms: | MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29681.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09237 |
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| Residue: | 267 |
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| Sequence: | MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
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| BDBM50072578 |
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| n/a |
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| Name | BDBM50072578 |
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| Synonyms: | (2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-phenyl-ethyl)-N*1*-hydroxy-3-isobutyl-succinamide | CHEMBL111104 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N2O4 |
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| Mol. Mass. | 436.5433 |
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| SMILES | CC(C)C[C@H]([C@H](CC=C)C(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(=O)c1ccccc1 |
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| Structure | 
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