Reaction Details |
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Target | Chloride anion exchanger |
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Ligand | BDBM82940 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1874150 (CHEMBL4375439) |
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IC50 | 10000±n/a nM |
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Citation | Lee, S; Cil, O; Haggie, PM; Verkman, AS 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem62:8330-8337 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chloride anion exchanger |
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Name: | Chloride anion exchanger |
Synonyms: | Chloride anion exchanger | Down-regulated in adenoma | Dra | Protein DRA | S26A3_MOUSE | Slc26a3 | Solute carrier family 26 member 3 |
Type: | PROTEIN |
Mol. Mass.: | 83598.25 |
Organism: | Mus musculus |
Description: | ChEMBL_119253 |
Residue: | 757 |
Sequence: | MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPI
ASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLG
TSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSG
IIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVL
ESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGC
NFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDY
PIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVA
IGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLG
LAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFA
NIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEE
LDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGL
RTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYS
TSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF
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BDBM82940 |
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n/a |
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Name | BDBM82940 |
Synonyms: | 2-[7-(2-bromobenzyl)oxy-2-keto-4,8-dimethyl-chromen-3-yl]acetic acid | 2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxidanylidene-chromen-3-yl]ethanoic acid | 2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxo-1-benzopyran-3-yl]acetic acid | 2-[7-[(2-bromophenyl)methoxy]-4,8-dimethyl-2-oxochromen-3-yl]acetic acid | MLS001213427 | SMR000540529 | cid_1295810 |
Type | Small organic molecule |
Emp. Form. | C20H17BrO5 |
Mol. Mass. | 417.25 |
SMILES | Cc1c(CC(O)=O)c(=O)oc2c(C)c(OCc3ccccc3Br)ccc12 |
Structure |
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