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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076895 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51119 (CHEMBL665732) | ||
| Ki | 122±n/a nM | ||
| Citation |  Beck, JP; Curry, MA; Chorvat, RJ; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:1185-8 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50076895 | |||
| n/a | |||
| Name | BDBM50076895 | ||
| Synonyms: | 3-(2-Bromo-4-isopropyl-phenyl)-5-methyl-7-morpholin-4-yl-3H-thiazolo[4,5-d]pyrimidine-2-thione | CHEMBL280449 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21BrN4OS2 | ||
| Mol. Mass. | 465.43 | ||
| SMILES | CC(C)c1ccc(c(Br)c1)-n1c2nc(C)nc(N3CCOCC3)c2sc1=S |(17.64,-23.83,;18.67,-22.68,;20.18,-22.98,;18.19,-21.21,;16.66,-20.89,;16.18,-19.45,;17.2,-18.29,;18.71,-18.6,;19.8,-17.51,;19.21,-20.06,;16.72,-16.84,;15.27,-16.37,;13.92,-17.14,;12.58,-16.37,;11.26,-17.14,;12.58,-14.83,;13.92,-14.06,;13.9,-12.52,;12.58,-11.75,;12.57,-10.21,;13.9,-9.44,;15.25,-10.2,;15.25,-11.75,;15.25,-14.83,;16.72,-14.35,;17.64,-15.59,;19.18,-15.59,)| | ||
| Structure | 
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