| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 2 |
|---|
| Ligand | BDBM50522522 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1886959 (CHEMBL4388636) |
|---|
| IC50 | 15000±n/a nM |
|---|
| Citation |  Washburn, A; Abdeen, S; Ovechkina, Y; Ray, AM; Stevens, M; Chitre, S; Sivinski, J; Park, Y; Johnson, J; Hoang, QQ; Chapman, E; Parish, T; Johnson, SM Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorg Med Chem Lett29:1665-1672 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 2 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 2 |
|---|
| Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 48481.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P17706 |
|---|
| Residue: | 415 |
|---|
| Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
|
|
|
|---|
| BDBM50522522 |
|---|
| n/a |
|---|
| Name | BDBM50522522 |
|---|
| Synonyms: | CHEMBL4590591 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H18ClN3O5S3 |
|---|
| Mol. Mass. | 596.097 |
|---|
| SMILES | Clc1ccc(s1)S(=O)(=O)Nc1ccc2oc(nc2c1)-c1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
