| Reaction Details |
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 | Report a problem with these data |
| Target | Thiosulfate sulfurtransferase |
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| Ligand | BDBM50186231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1891102 (CHEMBL4392929) |
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| IC50 | >100000±n/a nM |
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| Citation |  Stevens, M; Abdeen, S; Salim, N; Ray, AM; Washburn, A; Chitre, S; Sivinski, J; Park, Y; Hoang, QQ; Chapman, E; Johnson, SM HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett29:1106-1112 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thiosulfate sulfurtransferase |
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| Name: | Thiosulfate sulfurtransferase |
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| Synonyms: | 2.8.1.1 | Rhodanese | THTR_HUMAN | TST | Thiosulfate sulfurtransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33432.06 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118080 |
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| Residue: | 297 |
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| Sequence: | MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFD
IEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFG
HRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLV
DSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDL
SQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
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| BDBM50186231 |
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| n/a |
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| Name | BDBM50186231 |
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| Synonyms: | (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid | CHEMBL456 | ETHACRYNIC ACID | Edecrin | Etacrinic acid | Ethacrynate | Hydromedin | Methylenebutyrylphenoxyacetic acid | [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid | jm5b01461, Compound 72 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12Cl2O4 |
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| Mol. Mass. | 303.138 |
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| SMILES | CCC(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl |
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| Structure | 
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