| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM50004796 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1895329 (CHEMBL4397364) |
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| EC50 | 40±n/a nM |
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| Citation |  Reilly, SW; Riad, AA; Hsieh, CJ; Sahlholm, K; Jacome, DA; Griffin, S; Taylor, M; Weng, CC; Xu, K; Kirschner, N; Luedtke, RR; Parry, C; Malhotra, S; Karanicolas, J; Mach, RH Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D J Med Chem62:5132-5147 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A |
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| Type: | Enzyme |
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| Mol. Mass.: | 49303.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21728 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM50004796 |
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| n/a |
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| Name | BDBM50004796 |
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| Synonyms: | 8-Chloro-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol; hydrobromide | CHEMBL292418 | CHEMBL540857 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16ClNO |
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| Mol. Mass. | 273.757 |
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| SMILES | Oc1cc2C(CNCCc2cc1Cl)c1ccccc1 |
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| Structure | 
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