| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin-degrading enzyme |
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| Ligand | BDBM50477463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1897036 (CHEMBL4399071) |
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| IC50 | 100000±n/a nM |
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| Citation |  Leroux, F; Bosc, D; Beghyn, T; Hermant, P; Warenghem, S; Landry, V; Pottiez, V; Guillaume, V; Charton, J; Herledan, A; Urata, S; Liang, W; Sheng, L; Tang, WJ; Deprez, B; Deprez-Poulain, R Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening. Eur J Med Chem179:557-566 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Insulin-degrading enzyme |
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| Name: | Insulin-degrading enzyme |
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| Synonyms: | Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 117968.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14735 |
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| Residue: | 1019 |
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| Sequence: | MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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| BDBM50477463 |
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| n/a |
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| Name | BDBM50477463 |
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| Synonyms: | CHEBI:63334 | Rolitetracycline | SO-15659 | Syntetrin |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33N3O8 |
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| Mol. Mass. | 527.5662 |
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| SMILES | [H][C@@]12C[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(=O)NCN1CCCC1)=C(O)[C@H]2N(C)C |t:19,37| |
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| Structure | 
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