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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1
LigandBDBM50070209
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1897046 (CHEMBL4399081)
IC50 53000±n/a nM
Citation Leroux, F; Bosc, D; Beghyn, T; Hermant, P; Warenghem, S; Landry, V; Pottiez, V; Guillaume, V; Charton, J; Herledan, A; Urata, S; Liang, W; Sheng, L; Tang, WJ; Deprez, B; Deprez-Poulain, R Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening. Eur J Med Chem179:557-566 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Name:N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:DDAH | DDAH1 | DDAH1_HUMAN | Dimethylarginine dimethylaminohydrolase (DDAH-1) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) E78A | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L271G | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L30A | Dimethylarginine dimethylaminohydrolase 1 (DDAH1) | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Type:Protein
Mol. Mass.:31116.90
Organism:Homo sapiens (Human)
Description:O94760
Residue:285
Sequence:
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGL
QVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMK
DENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSM
AGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPE
EYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
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  Blast E-value cutoff:
BDBM50070209
n/a
NameBDBM50070209
Synonyms:Aciphex | CHEBI:8768 | LY-307640 | Rabeprazole
TypeSmall organic molecule
Emp. Form.C18H21N3O3S
Mol. Mass.359.443
SMILESCOCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C
Structure
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