| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C19 |
|---|
| Ligand | BDBM50527645 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1903443 (CHEMBL4405665) |
|---|
| IC50 | 25100±n/a nM |
|---|
| Citation |  Beatty, JW; Lindsey, EA; Thomas-Tran, R; Debien, L; Mandal, D; Jeffrey, JL; Tran, AT; Fournier, J; Jacob, SD; Yan, X; Drew, SL; Ginn, E; Chen, A; Pham, AT; Zhao, S; Jin, L; Young, SW; Walker, NP; Leleti, MR; Moschütz, S; Sträter, N; Powers, JP; Lawson, KV Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J Med Chem63:3935-3955 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C19 |
|---|
| Name: | Cytochrome P450 2C19 |
|---|
| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55935.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P33261 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
|
|
|
|---|
| BDBM50527645 |
|---|
| n/a |
|---|
| Name | BDBM50527645 |
|---|
| Synonyms: | CHEMBL4527142 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H14Cl2N8O |
|---|
| Mol. Mass. | 477.306 |
|---|
| SMILES | Clc1ccc(Cn2nccc2-c2cc3n(nnc3cn2)-c2ccc3[nH]c(=O)[nH]c3c2)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
