| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 4F12 |
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| Ligand | BDBM50527963 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1904210 (CHEMBL4406432) |
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| IC50 | 167000±n/a nM |
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| Citation |  Kowalski, JP; McDonald, MG; Pelletier, RD; Hanenberg, H; Wiek, C; Rettie, AE Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1. J Med Chem63:4824-4836 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 4F12 |
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| Name: | Cytochrome P450 4F12 |
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| Synonyms: | 1.14.14.1 | CP4FC_HUMAN | CYP4F12 | CYPIVF12 | Cytochrome P450 4F12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60317.77 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_109678 |
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| Residue: | 524 |
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| Sequence: | MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF
WGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK
DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH
LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL
QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID
VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC
LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV
VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ
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| BDBM50527963 |
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| n/a |
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| Name | BDBM50527963 |
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| Synonyms: | CHEMBL4557940 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20N4O2 |
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| Mol. Mass. | 276.3342 |
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| SMILES | OC(=O)CCCCCCCNn1nnc2ccccc12 |
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| Structure | 
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