| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50082964 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105067 (CHEMBL711313) |
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| IC50 | 20±n/a nM |
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| Citation |  Barlaam, B; Bird, TG; Lambert-Van Der Brempt, C; Campbell, D; Foster, SJ; Maciewicz, R New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors. J Med Chem42:4890-908 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50082964 |
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| n/a |
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| Name | BDBM50082964 |
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| Synonyms: | (2R,3S)-2-Cyclopentyl-N*4*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*1*-hydroxy-3-isobutyl-succinamide | CHEMBL29976 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H37N3O4 |
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| Mol. Mass. | 383.5255 |
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| SMILES | CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](C1CCCC1)C(=O)NO)C(C)(C)C |
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| Structure | 
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