Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50530002 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1911094 (CHEMBL4413540) |
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IC50 | 0.610000±n/a nM |
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Citation | Chen, Y; Yuan, X; Zhang, W; Tang, M; Zheng, L; Wang, F; Yan, W; Yang, S; Wei, Y; He, J; Chen, L Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy. J Med Chem62:1577-1592 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50530002 |
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n/a |
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Name | BDBM50530002 |
Synonyms: | CHEMBL4532398 |
Type | Small organic molecule |
Emp. Form. | C28H38N8O5 |
Mol. Mass. | 566.6519 |
SMILES | C[C@@H]1CN(CCO1)C(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(CCCCCCC(=O)NO)c2n1 |r| |
Structure |
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