| Reaction Details |
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 | Report a problem with these data |
| Target | Polyamine deacetylase HDAC10 |
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| Ligand | BDBM50530003 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1911098 (CHEMBL4413544) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Chen, Y; Yuan, X; Zhang, W; Tang, M; Zheng, L; Wang, F; Yan, W; Yang, S; Wei, Y; He, J; Chen, L Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy. J Med Chem62:1577-1592 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyamine deacetylase HDAC10 |
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| Name: | Polyamine deacetylase HDAC10 |
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| Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 71431.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q969S8 |
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| Residue: | 669 |
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| Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
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| BDBM50530003 |
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| n/a |
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| Name | BDBM50530003 |
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| Synonyms: | CHEMBL4552057 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N7O3 |
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| Mol. Mass. | 439.5108 |
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| SMILES | Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(CCCCCCC(=O)NO)c2n1 |
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| Structure | 
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