| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-beta |
|---|
| Ligand | BDBM50530341 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1911886 (CHEMBL4414332) |
|---|
| EC50 | 43000±n/a nM |
|---|
| Citation |  Pollinger, J; Gellrich, L; Schierle, S; Kilu, W; Schmidt, J; Kalinowsky, L; Ohrndorf, J; Kaiser, A; Heering, J; Proschak, E; Merk, D Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. J Med Chem62:2112-2126 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor RXR-beta |
|---|
| Name: | Retinoic acid receptor RXR-beta |
|---|
| Synonyms: | NR2B2 | Nuclear receptor subfamily 2 group B member 2 | RXRB | RXRB_HUMAN | Retinoic acid receptor RXR-beta | Retinoid X receptor beta | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56932.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_39045 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
|
|
|
|---|
| BDBM50530341 |
|---|
| n/a |
|---|
| Name | BDBM50530341 |
|---|
| Synonyms: | CHEMBL4471255 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H12ClN3O2S |
|---|
| Mol. Mass. | 309.771 |
|---|
| SMILES | Cc1ccccc1Nc1cc(Cl)nc(SCC(O)=O)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
