| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM50253802 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1911885 (CHEMBL4414331) |
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| EC50 | 27000±n/a nM |
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| Citation |  Pollinger, J; Gellrich, L; Schierle, S; Kilu, W; Schmidt, J; Kalinowsky, L; Ohrndorf, J; Kaiser, A; Heering, J; Proschak, E; Merk, D Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. J Med Chem62:2112-2126 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50820.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456363 |
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| Residue: | 462 |
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| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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| BDBM50253802 |
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| n/a |
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| Name | BDBM50253802 |
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| Synonyms: | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)propanoic acid | CHEMBL454691 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16ClN3O2S |
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| Mol. Mass. | 337.824 |
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| SMILES | CC(Sc1nc(Cl)cc(Nc2cccc(C)c2C)n1)C(O)=O |
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| Structure | 
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