Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Presenilin-1 |
---|
Ligand | BDBM50478375 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1925256 (CHEMBL4428328) |
---|
IC50 | 115±n/a nM |
---|
Citation | Kumar, R; Juillerat-Jeanneret, L; Golshayan, D Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. J Med Chem59:7719-37 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Presenilin-1 |
---|
Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
|
|
|
BDBM50478375 |
---|
n/a |
---|
Name | BDBM50478375 |
Synonyms: | CHEBI:86193 | CHEMBL255682 |
Type | Small organic molecule |
Emp. Form. | C23H26F2N2O4 |
Mol. Mass. | 432.4603 |
SMILES | C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H](C(=O)OC(C)(C)C)c1ccccc1 |r| |
Structure |
|