| Reaction Details |
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 | Report a problem with these data |
| Target | Heme oxygenase 2 |
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| Ligand | BDBM84805 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1930142 (CHEMBL4433393) |
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| IC50 | 18000±n/a nM |
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| Citation |  Salerno, L; Floresta, G; Ciaffaglione, V; Gentile, D; Margani, F; Turnaturi, R; Rescifina, A; Pittalą, V Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application. Eur J Med Chem167:439-453 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heme oxygenase 2 |
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| Name: | Heme oxygenase 2 |
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| Synonyms: | HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 35754.99 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | HO-2 obtained from rat brain was used in enzyme assays. |
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| Residue: | 315 |
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| Sequence: | MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
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| BDBM84805 |
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| n/a |
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| Name | BDBM84805 |
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| Synonyms: | 1-azolyl-4-phenyl-2-butanone, 7 |
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| Type | n/a |
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| Emp. Form. | C12H13N3O |
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| Mol. Mass. | 215.2511 |
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| SMILES | O=C(CCc1ccccc1)Cn1cncn1 |
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| Structure | 
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