| Reaction Details |
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 | Report a problem with these data |
| Target | Heme oxygenase 1 |
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| Ligand | BDBM50535264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1930143 (CHEMBL4433394) |
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| IC50 | 67600±n/a nM |
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| Citation |  Salerno, L; Floresta, G; Ciaffaglione, V; Gentile, D; Margani, F; Turnaturi, R; Rescifina, A; Pittalą, V Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application. Eur J Med Chem167:439-453 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heme oxygenase 1 |
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| Name: | Heme oxygenase 1 |
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| Synonyms: | HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 33005.15 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | HO-1 obtained from rat spleen was used in enzyme assays. |
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| Residue: | 289 |
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| Sequence: | MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
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| BDBM50535264 |
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| n/a |
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| Name | BDBM50535264 |
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| Synonyms: | CHEMBL4459358 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H22N2O |
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| Mol. Mass. | 246.348 |
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| SMILES | OC(Cn1ccnc1)C12CC3CC(CC(C3)C1)C2 |TLB:1:8:11.10.15:13,THB:1:8:11:15.14.13,16:8:11:15.14.13,16:14:11:8.17.9,9:8:11.10.15:13,9:10:13:8.17.16| |
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| Structure | 
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