| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50093091 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209040 |
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| Ki | 34±n/a nM |
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| Citation |  Reichard, GA; Ball, ZT; Aslanian, R; Anthes, JC; Shih, NY; Piwinski, JJ The design and synthesis of novel NK1/NK2 dual antagonists. Bioorg Med Chem Lett10:2329-32 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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| BDBM50093091 |
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| n/a |
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| Name | BDBM50093091 |
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| Synonyms: | 2-[(1R,2R)-1-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-2-(3,4-dichloro-phenyl)-4-(4-hydroxy-4-phenyl-piperidin-1-yl)-butylamino]-acetamide | CHEMBL405129 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H35Cl2F6N3O3 |
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| Mol. Mass. | 706.546 |
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| SMILES | NC(=O)CN[C@@H](COCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)[C@H](CCN1CCC(O)(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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