Reaction Details |
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Target | N-acylethanolamine-hydrolyzing acid amidase |
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Ligand | BDBM319796 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1977332 (CHEMBL4610467) |
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IC50 | 9.0±n/a nM |
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Citation | Malamas, MS; Farah, SI; Lamani, M; Pelekoudas, DN; Perry, NT; Rajarshi, G; Miyabe, CY; Chandrashekhar, H; West, J; Pavlopoulos, S; Makriyannis, A Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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N-acylethanolamine-hydrolyzing acid amidase |
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Name: | N-acylethanolamine-hydrolyzing acid amidase |
Synonyms: | ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa |
Type: | Enzyme |
Mol. Mass.: | 40306.53 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q5KTC7 |
Residue: | 362 |
Sequence: | MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
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BDBM319796 |
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n/a |
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Name | BDBM319796 |
Synonyms: | US10174015, Compound 9 |
Type | Small organic molecule |
Emp. Form. | C15H18ClNO3 |
Mol. Mass. | 295.761 |
SMILES | Clc1cccc(CCCCCC(=O)N2CCOC2=O)c1 |
Structure |
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