| Reaction Details |
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 | Report a problem with these data |
| Target | Transporter |
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| Ligand | BDBM50095136 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143125 |
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| Ki | 508±n/a nM |
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| Citation |  Tamiz, AP; Conti, P; Zhang, M; Johnson, KM; Kozikowski, AP A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents. Bioorg Med Chem Lett10:2741-3 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Transporter |
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| Name: | Transporter |
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| Synonyms: | Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66787.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1463061 |
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| Residue: | 597 |
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| Sequence: | MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF
YMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLN
LPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI
GLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG
INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTIN
CVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFL
MLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLT
LLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLL
FVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAY
GITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
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| BDBM50095136 |
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| n/a |
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| Name | BDBM50095136 |
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| Synonyms: | (3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid 4-[(3-trifluoromethyl-benzoylamino)-methyl]-benzylamide | CHEMBL92880 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29ClF3N3O2 |
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| Mol. Mass. | 544.008 |
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| SMILES | CN1CC[C@H]([C@@H](C1)C(=O)NCc1ccc(CNC(=O)c2cccc(c2)C(F)(F)F)cc1)c1ccc(Cl)cc1 |
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| Structure | 
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