| Reaction Details |
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 | Report a problem with these data |
| Target | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Ligand | BDBM50539246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1977818 (CHEMBL4610953) |
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| EC50 | 210±n/a nM |
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| Citation |  Atkinson, BN; Steadman, D; Mahy, W; Zhao, Y; Sipthorp, J; Bayle, ED; Svensson, F; Papageorgiou, G; Jeganathan, F; Frew, S; Monaghan, A; Bictash, M; Jones, EY; Fish, PV Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Palmitoleoyl-protein carboxylesterase NOTUM |
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| Name: | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Synonyms: | NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55706.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116492 |
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| Residue: | 496 |
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| Sequence: | MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVE
GNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRW
LLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFI
PYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLL
NVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNG
VVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGL
RLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHD
SHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQP
QGLEPSELLGMLSNGS
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| BDBM50539246 |
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| n/a |
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| Name | BDBM50539246 |
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| Synonyms: | CHEMBL4632439 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13F3N4O2S2 |
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| Mol. Mass. | 390.404 |
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| SMILES | CN1CN(CC1=O)C(=O)CSc1ncnc2sc(c(C)c12)C(F)(F)F |
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| Structure | 
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