| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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| Ligand | BDBM50541401 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1984204 (CHEMBL4617610) |
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| IC50 | 1000±n/a nM |
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| Citation |  Dubowchik, GM; Conway, CM; Xin, AW Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success. J Med Chem63:6600-6623 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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| Name: | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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| Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 327200 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Calcitonin gene-related peptide type 1 receptor |
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| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52980.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16602 |
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| Residue: | 461 |
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| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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| Component 2 |
| Name: | Receptor activity-modifying protein 1 |
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| Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 16992.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_100673 |
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| Residue: | 148 |
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| Sequence: | MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG
RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY
PFIVVPITVTLLVTALVVWQSKRTEGIV
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| BDBM50541401 |
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| n/a |
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| Name | BDBM50541401 |
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| Synonyms: | CHEMBL4634626 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H43Br2N7O5 |
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| Mol. Mass. | 789.557 |
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| SMILES | COc1ccccc1CCNC(=O)N[C@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN(CC1)c1ccncc1 |r| |
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| Structure | 
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