Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50102365 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201964 (CHEMBL882257) |
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Ki | 1450±n/a nM |
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Citation | Martínez-Esparza, J; Oficialdegui, AM; Pérez-Silanes, S; Heras, B; Orús, L; Palop, JA; Lasheras, B; Roca, J; Mourelle, M; Bosch, A; Del Castillo, JC; Tordera, R; Del Río, J; Monge, A New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. J Med Chem44:418-28 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50102365 |
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n/a |
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Name | BDBM50102365 |
Synonyms: | 1-(3-(4-methoxyphenoxy)-3-phenylpropyl)-4-(2-methoxyphenyl)piperazine | 1-[3-(4-Methoxy-phenoxy)-3-phenyl-propyl]-4-(2-methoxy-phenyl)-piperazine | CHEMBL135730 |
Type | Small organic molecule |
Emp. Form. | C27H32N2O3 |
Mol. Mass. | 432.5546 |
SMILES | COc1ccc(OC(CCN2CCN(CC2)c2ccccc2OC)c2ccccc2)cc1 |
Structure |
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