| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ephrin type-B receptor 6 |
|---|
| Ligand | BDBM50524284 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2014134 (CHEMBL4667712) |
|---|
| Kd | 710±n/a nM |
|---|
| Citation |  Asquith, CRM; Treiber, DK; Zuercher, WJ Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorg Med Chem Lett29:1727-1731 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ephrin type-B receptor 6 |
|---|
| Name: | Ephrin type-B receptor 6 |
|---|
| Synonyms: | EPHB6 | EPHB6_HUMAN | Ephrin receptor | Ephrin type-B receptor 6 | HEP | Tyrosine-protein kinase-defective receptor EPH-6 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 110701.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774437 |
|---|
| Residue: | 1021 |
|---|
| Sequence: | MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVS
VLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVS
GGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWA
VGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFA
SFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCR
CQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSD
PPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGG
GGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAIN
VSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTS
ETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSI
LGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRE
LAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRA
AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVA
AAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTT
SSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQK
DRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAI
GLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVE
V
|
|
|
|---|
| BDBM50524284 |
|---|
| n/a |
|---|
| Name | BDBM50524284 |
|---|
| Synonyms: | CHEMBL4443342 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H17BrN2O3 |
|---|
| Mol. Mass. | 389.243 |
|---|
| SMILES | COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC |
|---|
| Structure | 
|
|---|
Search and Browse
