| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase NLK |
|---|
| Ligand | BDBM50524289 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2014138 (CHEMBL4667716) |
|---|
| Kd | 690±n/a nM |
|---|
| Citation |  Asquith, CRM; Treiber, DK; Zuercher, WJ Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorg Med Chem Lett29:1727-1731 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase NLK |
|---|
| Name: | Serine/threonine-protein kinase NLK |
|---|
| Synonyms: | LAK1 | NLK | NLK_HUMAN | Serine/threonine protein kinase NLK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58306.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774580 |
|---|
| Residue: | 527 |
|---|
| Sequence: | MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
|
|
|
|---|
| BDBM50524289 |
|---|
| n/a |
|---|
| Name | BDBM50524289 |
|---|
| Synonyms: | CHEMBL535429 | TCMDC-138471 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17F3N2O3 |
|---|
| Mol. Mass. | 378.3451 |
|---|
| SMILES | COc1cc(Nc2ccnc3ccc(cc23)C(F)(F)F)cc(OC)c1OC |
|---|
| Structure | 
|
|---|
Search and Browse
