| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM50524289 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2014139 (CHEMBL4667717) |
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| Kd | 890±n/a nM |
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| Citation |  Asquith, CRM; Treiber, DK; Zuercher, WJ Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorg Med Chem Lett29:1727-1731 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 2 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 |
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| Type: | Protein |
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| Mol. Mass.: | 61201.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 540 |
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| Sequence: | MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
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| BDBM50524289 |
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| n/a |
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| Name | BDBM50524289 |
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| Synonyms: | CHEMBL535429 | TCMDC-138471 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17F3N2O3 |
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| Mol. Mass. | 378.3451 |
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| SMILES | COc1cc(Nc2ccnc3ccc(cc23)C(F)(F)F)cc(OC)c1OC |
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| Structure | 
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