Reaction Details |
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Target | Thymidylate synthase |
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Ligand | BDBM50107343 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_209962 (CHEMBL820618) |
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IC50 | 65±n/a nM |
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Citation | Tobias, SC; Borch, RF Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs. J Med Chem44:4475-80 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thymidylate synthase |
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Name: | Thymidylate synthase |
Synonyms: | TS | TSase | TYSY_MOUSE | Tyms |
Type: | PROTEIN |
Mol. Mass.: | 34957.15 |
Organism: | Mus musculus |
Description: | ChEMBL_1340097 |
Residue: | 307 |
Sequence: | MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
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BDBM50107343 |
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n/a |
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Name | BDBM50107343 |
Synonyms: | (4-Chloro-butyl)-methyl-phosphoramidic acid 5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 5-nitro-furan-2-ylmethyl ester | CHEMBL139442 |
Type | Small organic molecule |
Emp. Form. | C19H25ClFN4O10P |
Mol. Mass. | 554.848 |
SMILES | CN(CCCCCl)P(=O)(OCC1OC(CC1O)n1cc(F)c(=O)[nH]c1=O)OCc1ccc(o1)[N+]([O-])=O |
Structure |
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