Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM50050404 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_55100 (CHEMBL665360) |
---|
IC50 | 0.92±n/a nM |
---|
Citation | Debnath, AK Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase. J Med Chem45:41-53 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
BDBM50050404 |
---|
n/a |
---|
Name | BDBM50050404 |
Synonyms: | 6-[(2,5-Dimethyl-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL23383 |
Type | Small organic molecule |
Emp. Form. | C17H20N6 |
Mol. Mass. | 308.3809 |
SMILES | Cc1ccc(C)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 |
Structure |
|