Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50034929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55100 (CHEMBL665360) |
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IC50 | 0.84±n/a nM |
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Citation | Debnath, AK Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase. J Med Chem45:41-53 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50034929 |
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n/a |
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Name | BDBM50034929 |
Synonyms: | 6-[(2,5-Diethoxy-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine | 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE | CHEMBL279679 |
Type | Small organic molecule |
Emp. Form. | C19H24N6O2 |
Mol. Mass. | 368.4329 |
SMILES | CCOc1ccc(OCC)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 |
Structure |
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