| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50114608 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48534 (CHEMBL660279) |
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| IC50 | 20±n/a nM |
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| Citation |  Du, X; Guo, C; Hansell, E; Doyle, PS; Caffrey, CR; Holler, TP; McKerrow, JH; Cohen, FE Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem45:2695-707 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50114608 |
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| n/a |
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| Name | BDBM50114608 |
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| Synonyms: | (1E)-1-(3,4-dichlorophenyl)propan-1-one thiosemicarbazone | CHEMBL92099 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11Cl2N3S |
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| Mol. Mass. | 276.185 |
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| SMILES | CCC(=NNC(N)=S)c1ccc(Cl)c(Cl)c1 |w:3.3| |
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| Structure | 
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