| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 4 |
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| Ligand | BDBM50089901 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106689 (CHEMBL714670) |
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| EC50 | >1000000±n/a nM |
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| Citation |  Clausen, RP; Bräuner-Osborne, H; Greenwood, JR; Hermit, MB; Stensbøl, TB; Nielsen, B; Krogsgaard-Larsen, P Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid. J Med Chem45:4240-5 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 4 |
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| Name: | Metabotropic glutamate receptor 4 |
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| Synonyms: | GRM4_RAT | Gprc1d | Grm4 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 4 (mGlu4) | Mglur4 | mGlu4 | metabotropic glutamate 4 | metabotropic glutamate 4a |
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| Type: | Enzyme |
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| Mol. Mass.: | 101849.79 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P31423 |
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| Residue: | 912 |
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| Sequence: | MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQ
KSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIA
ATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALAT
KQTYVTYTNHAI
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| BDBM50089901 |
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| n/a |
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| Name | BDBM50089901 |
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| Synonyms: | 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid | 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid(S-HIBO) | CHEMBL88184 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H8N2O4 |
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| Mol. Mass. | 172.1387 |
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| SMILES | N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O |
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| Structure | 
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