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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Ligand | BDBM50561534 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2075115 (CHEMBL4730649) | ||
| IC50 | 600±n/a nM | ||
| Citation |  Vadukoot, AK; Sharma, S; Aretz, CD; Kumar, S; Gautam, N; Alnouti, Y; Aldrich, AL; Heim, CE; Kielian, T; Hopkins, CR Synthesis and SAR Studies of 1 ACS Med Chem Lett11:1848-1854 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
| Type: | Protein | ||
| Mol. Mass.: | 83318.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07343 | ||
| Residue: | 736 | ||
| Sequence: |
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| BDBM50561534 | |||
| n/a | |||
| Name | BDBM50561534 | ||
| Synonyms: | CHEMBL4765220 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H13Cl2FN4O | ||
| Mol. Mass. | 379.216 | ||
| SMILES | FC1CC(C1)NC(=O)c1nc2cccnc2n1-c1ccc(Cl)c(Cl)c1 |(66.16,-23.92,;64.62,-23.93,;63.54,-25.02,;62.45,-23.94,;63.53,-22.84,;60.91,-23.95,;60.13,-22.62,;60.89,-21.28,;58.59,-22.63,;57.69,-23.88,;56.22,-23.41,;54.88,-24.19,;53.54,-23.42,;53.55,-21.88,;54.87,-21.11,;56.21,-21.87,;57.67,-21.39,;58.14,-19.93,;57.11,-18.79,;57.57,-17.33,;59.08,-16.99,;59.54,-15.52,;60.12,-18.13,;61.62,-17.8,;59.65,-19.6,)| | ||
| Structure | 
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