Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 1 |
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Ligand | BDBM50561821 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2076055 (CHEMBL4731589) |
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IC50 | 9.0±n/a nM |
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Citation | Hatcher, JM; Yang, G; Wang, L; Ficarro, SB; Buhrlage, S; Wu, H; Marto, JA; Treon, SP; Gray, NS Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma. ACS Med Chem Lett11:2238-2243 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 1 |
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Name: | Interleukin-1 receptor-associated kinase 1 |
Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) |
Type: | Enzyme |
Mol. Mass.: | 76536.81 |
Organism: | Homo sapiens (Human) |
Description: | P51617 |
Residue: | 712 |
Sequence: | MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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BDBM50561821 |
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n/a |
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Name | BDBM50561821 |
Synonyms: | CHEMBL4782804 |
Type | Small organic molecule |
Emp. Form. | C25H20N6O3 |
Mol. Mass. | 452.4647 |
SMILES | C=CC(=O)Nc1cccc(c1)C(=O)Nc1ccc(NC(=O)c2cccc(n2)-c2ccn[nH]2)cc1 |
Structure |
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