| Reaction Details |
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 | Report a problem with these data |
| Target | Monoacylglycerol lipase ABHD6 |
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| Ligand | BDBM50562158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2077558 (CHEMBL4733349) |
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| IC50 | >10000±n/a nM |
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| Citation |  Granchi, C; Bononi, G; Ferrisi, R; Gori, E; Mantini, G; Glasmacher, S; Poli, G; Palazzolo, S; Caligiuri, I; Rizzolio, F; Canzonieri, V; Perin, T; Gertsch, J; Sodi, A; Giovannetti, E; Macchia, M; Minutolo, F; Tuccinardi, T; Chicca, A Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem209:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoacylglycerol lipase ABHD6 |
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| Name: | Monoacylglycerol lipase ABHD6 |
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| Synonyms: | 2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38341.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105457 |
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| Residue: | 337 |
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| Sequence: | MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYST
DNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
NFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVEL
LENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
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| BDBM50562158 |
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| n/a |
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| Name | BDBM50562158 |
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| Synonyms: | CHEMBL4747585 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22FNO3S |
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| Mol. Mass. | 435.51 |
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| SMILES | Oc1ccc(F)c(c1)C(=O)N1CCC(CC1)C(=O)c1ccc(Sc2ccccc2)cc1 |
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| Structure | 
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