Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50126483 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_208513 |
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Ki | 0.750000±n/a nM |
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Citation | Sanderson, PE; Cutrona, KJ; Savage, KL; Naylor-Olsen, AM; Bickel, DJ; Bohn, DL; Clayton, FC; Krueger, JA; Lewis, SD; Lucas, BJ; Lyle, EA; Wallace, AA; Welsh, DC; Yan, Y 3-amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors. Bioorg Med Chem Lett13:1441-4 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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BDBM50126483 |
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n/a |
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Name | BDBM50126483 |
Synonyms: | 2-[3-Amino-4-(cyclobutylmethyl-sulfamoyl)-6-methyl-2-oxo-2H-pyridin-1-yl]-N-(6-amino-2-methyl-pyridin-3-ylmethyl)-acetamide | CHEMBL32661 |
Type | Small organic molecule |
Emp. Form. | C20H28N6O4S |
Mol. Mass. | 448.539 |
SMILES | Cc1cc(c(N)c(=O)n1CC(=O)NCc1ccc(N)nc1C)S(=O)(=O)NCC1CCC1 |
Structure |
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