| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50127149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54971 (CHEMBL666700) |
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| IC50 | 14000±n/a nM |
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| Citation |  Rosowsky, A; Forsch, RA; Queener, SF Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS. J Med Chem46:1726-36 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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| BDBM50127149 |
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| n/a |
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| Name | BDBM50127149 |
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| Synonyms: | 3-{3-[3-(2,4-Diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenyl]-prop-2-ynyloxy}-benzoic acid | CHEMBL35080 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N4O4 |
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| Mol. Mass. | 404.4186 |
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| SMILES | COc1ccc(cc1Cc1cnc(N)nc1N)C#CCOc1cccc(c1)C(O)=O |
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| Structure | 
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