| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50566094 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2094480 (CHEMBL4775743) |
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| IC50 | 1.9±n/a nM |
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| Citation |  Kang, Z; Wang, C; Tong, Y; Li, Y; Gao, Y; Hou, S; Hao, M; Han, X; Wang, B; Wang, Q; Zhang, C Novel Nonsecosteroidal Vitamin D Receptor Modulator Combined with Gemcitabine Enhances Pancreatic Cancer Therapy through Remodeling of the Tumor Microenvironment. J Med Chem64:629-643 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 48288.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11473 |
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| Residue: | 427 |
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| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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| BDBM50566094 |
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| n/a |
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| Name | BDBM50566094 |
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| Synonyms: | CHEMBL4796961 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H40O3 |
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| Mol. Mass. | 412.6047 |
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| SMILES | [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1/C[C@@H](O)C[C@H](O)C1=C)[C@H](C)\C=C\[C@@H](O)C1CC1 |r| |
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| Structure | 
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