| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cystic fibrosis transmembrane conductance regulator |
|---|
| Ligand | BDBM50130981 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_44471 |
|---|
| Kd | 220000±n/a nM |
|---|
| Citation |  Sammelson, RE; Ma, T; Galietta, LJ; Verkman, AS; Kurth, MJ 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett13:2509-12 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cystic fibrosis transmembrane conductance regulator |
|---|
| Name: | Cystic fibrosis transmembrane conductance regulator |
|---|
| Synonyms: | Abcc7 | CFTR_RAT | Cftr |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 167862.06 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_44471 |
|---|
| Residue: | 1476 |
|---|
| Sequence: | MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDRE
QASKKKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIA
IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
ISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAIL
GKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSA
YMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQI
WYDSLGMIRKIQDFLQTQEYKVLEYNLMFTGLVMENVTAFWEEGFQELLEKVQLNNDDRK
TSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEG
IIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTV
LGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTR
ILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSS
ILTETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIE
GESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQ
RTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTT
WNTYLRYFTLHRGLFAVLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVV
VITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFN
KLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAV
FILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLH
TANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQW
AVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTW
PSGGEMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIK
GEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGL
KSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVI
RRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRALSSS
EKMKLFHGRHSSKQKPRTQITAVKEETEEEVQETRL
|
|
|
|---|
| BDBM50130981 |
|---|
| n/a |
|---|
| Name | BDBM50130981 |
|---|
| Synonyms: | 3-[2-(4-Bromo-benzyloxy)-phenyl]-5-chloromethyl-isoxazole | CHEMBL83758 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13BrClNO2 |
|---|
| Mol. Mass. | 378.648 |
|---|
| SMILES | ClCc1cc(no1)-c1ccccc1OCc1ccc(Br)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
