Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Cystic fibrosis transmembrane conductance regulator |
---|
Ligand | BDBM50130987 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_44471 |
---|
Kd | 59000±n/a nM |
---|
Citation | Sammelson, RE; Ma, T; Galietta, LJ; Verkman, AS; Kurth, MJ 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett13:2509-12 (2003) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cystic fibrosis transmembrane conductance regulator |
---|
Name: | Cystic fibrosis transmembrane conductance regulator |
Synonyms: | Abcc7 | CFTR_RAT | Cftr |
Type: | PROTEIN |
Mol. Mass.: | 167862.06 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_44471 |
Residue: | 1476 |
Sequence: | MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDRE
QASKKKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIA
IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
ISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAIL
GKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSA
YMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQI
WYDSLGMIRKIQDFLQTQEYKVLEYNLMFTGLVMENVTAFWEEGFQELLEKVQLNNDDRK
TSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEG
IIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTV
LGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTR
ILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSS
ILTETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIE
GESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQ
RTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTT
WNTYLRYFTLHRGLFAVLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVV
VITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFN
KLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAV
FILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLH
TANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQW
AVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTW
PSGGEMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIK
GEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGL
KSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVI
RRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRALSSS
EKMKLFHGRHSSKQKPRTQITAVKEETEEEVQETRL
|
|
|
BDBM50130987 |
---|
n/a |
---|
Name | BDBM50130987 |
Synonyms: | 5-Chloromethyl-3-[2-(4-methoxy-benzyloxy)-phenyl]-4,5-dihydro-isoxazole | CHEMBL81938 |
Type | Small organic molecule |
Emp. Form. | C18H18ClNO3 |
Mol. Mass. | 331.793 |
SMILES | COc1ccc(COc2ccccc2C2=NOC(CCl)C2)cc1 |t:15| |
Structure |
|