Reaction Details |
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Target | Cystic fibrosis transmembrane conductance regulator |
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Ligand | BDBM50130996 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_44471 |
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Kd | 23000±n/a nM |
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Citation | Sammelson, RE; Ma, T; Galietta, LJ; Verkman, AS; Kurth, MJ 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett13:2509-12 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cystic fibrosis transmembrane conductance regulator |
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Name: | Cystic fibrosis transmembrane conductance regulator |
Synonyms: | Abcc7 | CFTR_RAT | Cftr |
Type: | PROTEIN |
Mol. Mass.: | 167862.06 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_44471 |
Residue: | 1476 |
Sequence: | MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDRE
QASKKKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIA
IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
ISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAIL
GKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSA
YMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQI
WYDSLGMIRKIQDFLQTQEYKVLEYNLMFTGLVMENVTAFWEEGFQELLEKVQLNNDDRK
TSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEG
IIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTV
LGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTR
ILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSS
ILTETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIE
GESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQ
RTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTT
WNTYLRYFTLHRGLFAVLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVV
VITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFN
KLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAV
FILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLH
TANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQW
AVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTW
PSGGEMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIK
GEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGL
KSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVI
RRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRALSSS
EKMKLFHGRHSSKQKPRTQITAVKEETEEEVQETRL
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BDBM50130996 |
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n/a |
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Name | BDBM50130996 |
Synonyms: | 2-{3-[2-(4-Bromo-benzyloxy)-phenyl]-isoxazol-5-yl}-ethanol | CHEMBL85369 |
Type | Small organic molecule |
Emp. Form. | C18H16BrNO3 |
Mol. Mass. | 374.229 |
SMILES | OCCc1cc(no1)-c1ccccc1OCc1ccc(Br)cc1 |
Structure |
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