| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50567047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2102249 (CHEMBL4810645) |
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| Kd | 70±n/a nM |
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| Citation |  Henderson, SH; Sorrell, F; Bennett, J; Fedorov, O; Hanley, MT; Godoi, PH; Ruela de Sousa, R; Robinson, S; Ashall-Kelly, A; Hopkins Navratilova, I; Walter, DS; Elkins, JM; Ward, SE Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. J Med Chem64:11709-11728 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 |
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| Type: | Protein |
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| Mol. Mass.: | 57322.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49759 |
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| Residue: | 484 |
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| Sequence: | MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
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| BDBM50567047 |
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| n/a |
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| Name | BDBM50567047 |
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| Synonyms: | CHEMBL4848254 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N6 |
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| Mol. Mass. | 240.2639 |
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| SMILES | CN(C)c1nccc(n1)-c1cnn2ncccc12 |
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| Structure | 
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