| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50569039 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2107361 (CHEMBL4816036) |
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| Ki | 8.1±n/a nM |
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| Citation |  Shaldam, M; Eldehna, WM; Nocentini, A; Elsayed, ZM; Ibrahim, TM; Salem, R; El-Domany, RA; Capasso, C; Abdel-Aziz, HA; Supuran, CT Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors. Eur J Med Chem216:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50569039 |
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| n/a |
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| Name | BDBM50569039 |
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| Synonyms: | CHEMBL4860334 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12BrN3O4S |
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| Mol. Mass. | 410.242 |
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| SMILES | NS(=O)(=O)c1cccc(NC(=O)Nc2cc3cc(Br)ccc3o2)c1 |
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| Structure | 
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