Reaction Details |
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Target | Carbapenem-hydrolyzing beta-lactamase KPC |
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Ligand | BDBM50569695 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2109934 (CHEMBL4818609) |
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Ki | 5230±n/a nM |
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Citation | Romero, E; Oueslati, S; Benchekroun, M; D'Hollander, ACA; Ventre, S; Vijayakumar, K; Minard, C; Exilie, C; Tlili, L; Retailleau, P; Zavala, A; Elisée, E; Selwa, E; Nguyen, LA; Pruvost, A; Naas, T; Iorga, BI; Dodd, RH; Cariou, K Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of ?-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D). Eur J Med Chem219:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbapenem-hydrolyzing beta-lactamase KPC |
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Name: | Carbapenem-hydrolyzing beta-lactamase KPC |
Synonyms: | BLKPC_KLEOX | Carbapenem-hydrolyzing beta-lactamase KPC-2 | bla | kpc | kpc2 |
Type: | Protein |
Mol. Mass.: | 31116.99 |
Organism: | n/a |
Description: | Q848S6 |
Residue: | 293 |
Sequence: | MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYR
AEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAE
LSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTS
SPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVY
GTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
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BDBM50569695 |
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n/a |
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Name | BDBM50569695 |
Synonyms: | CHEMBL4875502 |
Type | Small organic molecule |
Emp. Form. | C26H21BrN2O |
Mol. Mass. | 457.362 |
SMILES | COc1ccc(cc1)N1C(C\C1=N/c1ccc(Br)cc1)c1ccc2ccccc2c1 |
Structure |
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