Reaction Details | |||
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Target | Apelin receptor | ||
Ligand | BDBM50570421 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2112153 (CHEMBL4821003) | ||
EC50 | 180±n/a nM | ||
Citation | Johnson, JA; Kim, SH; Jiang, J; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; He, Y; Chen, XQ; Xu, C; Galella, MA; Wang, T; Gordon, DA; Wexler, RR; Finlay, HJ Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate. J Med Chem64:3086-3099 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Apelin receptor | |||
Name: | Apelin receptor | ||
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 42664.06 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35414 | ||
Residue: | 380 | ||
Sequence: |
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BDBM50570421 | |||
n/a | |||
Name | BDBM50570421 | ||
Synonyms: | CHEMBL4878068 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H24ClN3O5 | ||
Mol. Mass. | 481.928 | ||
SMILES | CCCCc1[nH]c(=O)c(-c2nnc(o2)-c2ccc(Cl)cc2)c(O)c1-c1c(OC)cccc1OC |(53.34,-14.22,;54.68,-14.98,;56.01,-14.2,;57.35,-14.96,;58.68,-14.19,;58.67,-12.65,;60,-11.87,;60,-10.33,;61.34,-12.63,;62.67,-11.86,;62.82,-10.33,;64.33,-10,;65.1,-11.34,;64.08,-12.48,;66.64,-11.49,;67.26,-12.9,;68.79,-13.06,;69.69,-11.81,;71.22,-11.97,;69.05,-10.4,;67.53,-10.25,;61.34,-14.17,;62.67,-14.95,;60.01,-14.95,;60.02,-16.48,;58.69,-17.25,;57.36,-16.49,;56.03,-17.26,;58.69,-18.8,;60.02,-19.57,;61.36,-18.8,;61.35,-17.24,;62.69,-16.47,;64.02,-17.24,)| | ||
Structure |