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TargetApelin receptor
LigandBDBM50570421
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2112153 (CHEMBL4821003)
EC50 180±n/a nM
Citation Johnson, JAKim, SHJiang, JPhillips, MSchumacher, WABostwick, JSGargalovic, PSOnorato, JMLuk, CEGeneraux, CHe, YChen, XQXu, CGalella, MAWang, TGordon, DAWexler, RRFinlay, HJ Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate. J Med Chem64:3086-3099 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apelin receptor
Name:Apelin receptor
Synonyms:AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:Enzyme Catalytic Domain
Mol. Mass.:42664.06
Organism:Homo sapiens (Human)
Description:P35414
Residue:380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
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  Blast E-value cutoff:
BDBM50570421
n/a
NameBDBM50570421
Synonyms:CHEMBL4878068
TypeSmall organic molecule
Emp. Form.C25H24ClN3O5
Mol. Mass.481.928
SMILESCCCCc1[nH]c(=O)c(-c2nnc(o2)-c2ccc(Cl)cc2)c(O)c1-c1c(OC)cccc1OC |(53.34,-14.22,;54.68,-14.98,;56.01,-14.2,;57.35,-14.96,;58.68,-14.19,;58.67,-12.65,;60,-11.87,;60,-10.33,;61.34,-12.63,;62.67,-11.86,;62.82,-10.33,;64.33,-10,;65.1,-11.34,;64.08,-12.48,;66.64,-11.49,;67.26,-12.9,;68.79,-13.06,;69.69,-11.81,;71.22,-11.97,;69.05,-10.4,;67.53,-10.25,;61.34,-14.17,;62.67,-14.95,;60.01,-14.95,;60.02,-16.48,;58.69,-17.25,;57.36,-16.49,;56.03,-17.26,;58.69,-18.8,;60.02,-19.57,;61.36,-18.8,;61.35,-17.24,;62.69,-16.47,;64.02,-17.24,)|
Structure
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