Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM50570422

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2112154 (CHEMBL4821004)

EC50

15±n/a nM

Citation

Johnson, JA; Kim, SH; Jiang, J; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; He, Y; Chen, XQ; Xu, C; Galella, MA; Wang, T; Gordon, DA; Wexler, RR; Finlay, HJ Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate. J Med Chem64:3086-3099 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

42351.61

Organism:

Rattus norvegicus

Description:

ChEMBL_10710

Residue:

377

Sequence:

MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRR
SADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTG
LSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCY
MDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRK
RRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNS
CLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGG
EPMHEKSIPYSQETLVD

BDBM50570422

n/a

Name

BDBM50570422

Synonyms:

CHEMBL4852391

Type

Small organic molecule

Emp. Form.

C25H22ClN3O5

Mol. Mass.

479.912

SMILES

COc1cccc(OC)c1-c1c(O)c(-c2nnc(Cc3ccc(Cl)cc3)o2)c(=O)[nH]c1C1CC1 |(.41,-28.21,;1.74,-27.44,;3.07,-28.2,;3.07,-29.75,;4.4,-30.52,;5.74,-29.75,;5.73,-28.19,;7.07,-27.42,;8.4,-28.19,;4.4,-27.43,;4.39,-25.9,;5.72,-25.12,;7.05,-25.9,;5.72,-23.59,;7.05,-22.81,;7.2,-21.28,;8.71,-20.95,;9.48,-22.29,;11.01,-22.44,;11.64,-23.85,;10.74,-25.09,;11.37,-26.5,;12.9,-26.65,;13.52,-28.06,;13.8,-25.4,;13.17,-24,;8.45,-23.43,;4.38,-22.82,;4.38,-21.28,;3.05,-23.6,;3.06,-25.14,;1.73,-25.91,;.18,-25.93,;.96,-27.26,)|

Structure