| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1B |
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| Ligand | BDBM50139506 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1346 |
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| Ki | 140±n/a nM |
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| Citation |  Egle, I; MacLean, N; Demchyshyn, L; Edwards, L; Slassi, A; Tehim, A 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands. Bioorg Med Chem Lett14:727-9 (2004) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1B |
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| Name: | 5-hydroxytryptamine receptor 1B |
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| Synonyms: | 5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43579.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells |
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| Residue: | 390 |
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| Sequence: | MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL
KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE
KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL
NSLINPIIYTMSNEDFKQAFHKLIRFKCTS
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| BDBM50139506 |
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| n/a |
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| Name | BDBM50139506 |
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| Synonyms: | 5-[1-(4-Methoxy-benzenesulfonyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole | CHEMBL349675 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31N3O3S |
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| Mol. Mass. | 465.608 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)N1CCC(=CC1)c1ccc2[nH]cc(CCN3CCCC3)c2c1 |c:15| |
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| Structure | 
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